＊支援およびプロジェクト内連携の論文

Sajiki Y, Konnai S, Okagawa T, Maekawa N, Nakamura H, Kato Y, Suzuki Y, Murata S, Ohashi K
A TLR7 agonist activates bovine Th1 response and exerts antiviral activity against bovine leukemia virus
Dev Comp Immunol., 114, 103847, https://doi.org/10.1016/j.dci.2020.103847, 2021 (PDF)
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Yamato Sajiki, Satoru Konnai, Zimeng Cai, Kensuke Takada, Tomohiro Okagawa, Naoya Maekawa, Sotaro Fujisawa, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi
Enhanced immunotherapeutic efficacy of anti-PD-L1 antibody by combination with EP4 antagonist
ImmunoHorizons, 4 (12) 837-850; DOI: https://doi.org/10.4049/immunohorizons.2000089, 2020 (PDF)
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Kamoto S, Shinada M, Kato D, Yoshimoto S, Ikeda N, Tsuboi M, Yoshitake R, Eto S, Hashimoto Y, Takahashi Y, Chambers J, Uchida K, Kaneko MK, Fujita N, Nishimura R, Kato Y, Nakagawa T.
Phase I/II Clinical Trial of the Anti-Podoplanin Monoclonal Antibody Therapy in Dogs with Malignant Melanoma
Cells, 9(11), 2529; https://doi.org/10.3390/cells9112529, 2020 (PDF)
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Ganbaatar O, Konnai S, Okagawa T, Nojima Y, Maekawa N, Minato E, Kobayashi A, Ando R, Sasaki N, Miyakoshi D, Ichii O, Kato Y, Suzuki Y, Murata S, Ohashi K.
Characterization of anti-PD-L1 blocking antibody in horse and PD-L1 expression in equine malignant melanoma
PLoS One, 15(11):e0234218., doi: 10.1371/journal.pone.0234218, 2020 (PDF)
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Miura K, Yoshida H, Nosaki S, Kaneko MK, Kato Y.
RAP tag and PMab-2 antibody: a tagging system for detecting and purifying proteins in plant cells
Front. Plant Sci.,11, 510444, doi: 10.3389/fpls.2020.510444, 2020 (PDF)
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Tomokazu Ohishi, Yukinari Kato, Mika K. Kaneko, Shun-ichi Ohba, Hiroyuki Inoue, Akiko Harakawa, Manabu Kawada.
Anti-metastatic activity of an anti-EGFR monoclonal antibody against metastatic colorectal cancer with KRAS p.G13D mutation.
Int. J. Mol. Sci., 21(17), 6037; https://doi.org/10.3390/ijms21176037, 2020 (PDF)
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Mizuno T, Kato Y, Kaneko MK, Sakai Y, Shiga T, Kato M, Tsukui T, Takemoto H, Tokimasa A, Baba K, Nemoto Y, Sakai O, Igase M.
Generation of a canine anti-canine CD20 antibody for canine lymphoma treatment
Sci. Rep., 10, 11476, https://doi.org/10.1038/s41598-020-68470-9, 2020 (PDF)
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Mukai C, Choi E, Sams KL, Klampen EZ, Anguish L, Marks BA, Rice EJ, Wang Z, Choate LA, Chou SP, Kato Y, Miller AD, Danko CG, Coonrod SA.
Chromatin run-on sequencing analysis finds that ECM remodeling plays an important role in canine hemangiosarcoma pathogenesis 
BMC Veterinary Research, 16:206, DOI: 10.1186/s12917-020-02395-3, 2020 (PDF)
抗体バンクからの提供

Akiyama G, Saraswathy S, Bogarin T, Pan X, Barron E, Wong TT, Kaneko MK, Kato Y, Hong Y, Huang AS.
Functional, Structural, and Molecular Identification of Lymphatic Outflow from Subconjunctival Blebs  
Exp Eye Res.,196, 108049, https://doi.org/10.1016/j.exer.2020.108049, 2020 (PDF)
抗体バンクからの提供

Nishinaga Y, Sato K, Yasui H, Taki S, Takahashi K, Shimizu M, Endo R, Koike C, Kuramoto N, Nakamura S, Fukui T, Yukawa H, Baba Y, K Kaneko M, Chen-Yoshikawa TF, Kobayashi H, Kato Y, Hasegawa Y.
Targeted Phototherapy for Malignant Pleural Mesothelioma: Near-Infrared Photoimmunotherapy Targeting Podoplanin
Cells,9(4), 1019; https://doi.org/10.3390/cells9041019, 2020 (PDF)
抗体バンクからの提供

Shinada M, Kato D, Kamoto S, Yoshimoto S, Tsuboi M, Yoshitake R, Eto S, Ikeda N, Saeki K, Hashimoto Y, Takahashi Y, Chambers J, Uchida K, Kaneko MK, Fujita N, Nishimura R, Kato Y, Nakagawa T.
PDPN is expressed in various types of canine tumors and its silencing induces apoptosis and cell cycle arrest in canine malignant melanoma 
Cells, 9(5):E1136. doi: 10.3390/cells9051136., 2020 (PDF)
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Taiji Kuwata, Kazue Yoneda, Masataka Mori, Masatoshi Kanayama, Koji Kuroda, Mika K. Kaneko, Yukinari Kato, Fumihiro Tanaka
Effective detection of circulating tumor cells (CTCs) in malignant pleural mesothelioma (MPM) with the "universal" CTC-chip and an anti-podoplanin antibody NZ-1.2
Cells, 9(4), 888; https://doi.org/10.3390/cells9040888, 2020
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Yasukawa M, Ando Y, Yamashita T, Matsuda Y, Shoji S, Morioka MS, Kawaji H, Shiozawa K, Machitani M, Abe T, Yamada S, Kaneko MK, Kato Y, Furuta Y, Kondo T, Shirouzu M, Hayashizaki Y, Kaneko S, Masutomi K.
CDK1 dependent phosphorylation of hTERT contributes to cancer progression
Nat Commun.;11(1):1557. doi: 10.1038/s41467-020-15289-7., 2020
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Goto S, Konnai S, Hirano Y, Kohara J, Okagawa T, Maekawa N, Sajiki Y, Watari K, Minato E, Kobayashi A, Gondaira S, Higuchi H, Koiwa M, Tajima M, Taguchi E, Uemura R, Yamada S, Kaneko M, Kato Y, Yamamoto K, Toda M, Suzuki Y, Murata S, Ohashi K.
Upregulation of PD-L1 expression by prostaglandin E2 and the enhancement of IFN-γ by anti-PD-L1 antibody combined with a COX-2 inhibitor in Mycoplasma bovis infection
Front. Vet. Sci., 7:12. doi: 10.3389/fvets.2020.00012, 2020　(PDF)
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Goto S, Konnai S, Hirano Y, Kohara J, Okagawa T, Maekawa N, Sajiki Y, Watari K, Minato E, Kobayashi A, Gondaira S, Higuchi H, Koiwa M, Tajima M, Taguchi E, Ishida M, Uemura R, Yamada S, Kaneko M, Kato Y, Yamamoto K, Toda M, Suzuki Y, Murata S, Ohashi K.
Clinical efficacy of the combined treatment of anti-PD-L1 rat-bovine chimeric antibody with a COX-2 inhibitor in calves infected with Mycoplasma bovis
Jpn. J. Vet. Res., 68: 77-90, http://hdl.handle.net/2115/78601,2020,
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Sato M, Matsumoto M, Saiki Y, Alam M, Nishizawa H, Rokugo M, Brydun A, Yamada S, Kaneko MK, Funayama R, Ito M, Kato Y, Nakayama K, Unno M, Igarashi K.
BACH1 promotes pancreatic cancer metastasis by repressing epithelial genes and enhancing epithelial-mesenchymal transition
Cancer Res., 80(6):1279-1292.,doi: 10.1158/0008-5472.CAN-18-4099., 2020 (PDF)
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Sakamoto S, Inoue H, Kaneko MK, Ogasawara S, Kajikawa M, Urano S, Ohba SI, Kato Y, Kawada M.
Generation and evaluation of a chimeric antibody against coxsackievirus and adenovirus receptor for cancer therapy
Cancer Sci., 110(11):3595-3602, https://doi.org/10.1111/cas.14196, 2019, (PDF)
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Sajiki Y, Konnai S, Okagawa T, Nishimori A, Maekawa N, Goto S, Watari K, Minato E, Kobayashi A, Kohara J, Yamada S, Kaneko MK, Kato Y, Takahashi H, Terasaki N, Takeda A, Yamamoto K, Toda M, Suzuki Y, Murata S, Ohashi K.
Prostaglandin E2–Induced Immune Exhaustion and Enhancement of Antiviral Effects by Anti–PD-L1 Antibody Combined with COX-2 Inhibitor in Bovine Leukemia Virus Infection
J Immunol, 203(5):1313-1324, DOI: https://doi.org/10.4049/jimmunol.1900342, 2019 (PDF)
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Jangphattananont N, Sato H, Imamura R, Sakai K, Terakado Y, Murakami K, Barker N, Oshima H, Oshima M, Takagi J, Kato Y, Yano S, Matsumoto K.
Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach
Int. J. Mol. Sci.,20(12), 2955; https://doi.org/10.3390/ijms20122955, 2019 (PDF)
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Sakai K, Passioura T, Sato H, Ito K, Furuhashi H, Umitsu M, Takagi J, Kato Y, Mukai H, Warashina S, Zouda M, Watanabe Y, Yano S, Shibata M, Suga H, Matsumoto K.
Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor.
Nat Chem Biol., 15(6):598-606. doi: 10.1038/s41589-019-0285-7, 2019　(PDF)
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Sudo H, Tsuji AB, Sugyo A, Saga T, Kaneko MK, Kato Y, Higashi T.
Therapeutic efficacy evaluation of radioimmunotherapy with 90Y-labeled anti-podoplanin antibody NZ-12 for mesothelioma
Cancer Sci., 110(5):1653-1664, https://doi.org/10.1111/cas.13979, 2019 (PDF)
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Inoue M, Sakuta N, Watanabe S, Zhang Y, Yoshikaie K, Tanaka Y, Ushioda R, Kato Y, Takagi J, Tsukazaki T, Nagata K, Inaba K.
Structural Basis of Sarco/Endoplasmic Reticulum Ca2+-ATPase 2b Regulation via Transmembrane Helix Interplay
Cell Rep., 27(4):1221-1230.e3. doi: 10.1016/j.celrep.2019.03.106., 2019 (PDF)
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Tamura R, Oi R, Akashi S, Kaneko MK, Kato Y, Nogi T
Application of the NZ-1 Fab as a crystallization chaperone for PA tag-inserted target proteins
Protein Sci. 28(4), 823-836, https://doi.org/10.1002/pro.3580, 2019 (PDF)
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Kohei Kiname, Sho Yoshimoto, Daiki Kato, Masaya Tsuboi, Yuiko Tanaka, Ryohei Yoshitake, Shotaro Eto, Masahiro Shinada, James Chambers, Kohei Saeki, Ryohei Kinoshita, Shinji Yamada, Kazuyuki Uchida, Mika K. Kaneko, Ryohei Nishimura, Yukinari Kato, Takayuki Nakagawa
Evaluation of immunohistochemical staining with PMab-38, an anti-dog podoplanin monoclonal antibody, in various canine tumor tissues
Jpn. J. Vet. Res., 67(1); 25-34, 2019 (PDF)
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Sajiki Y, Konnai S, Okagawa T, Nishimori A, Maekawa N, Goto S, Ikebuchi R, Nagata R, Kawaji S, Kagawa Y, Yamada S, Kato Y, Nakajima C, Suzuki Y, Murata S, Mori Y, Ohashi K.
Prostaglandin E2 induction suppresses the Th1 immune responses in cattle with Johne's disease.
Infect Immun., 2018 Feb 26. pii: IAI.00910-17. doi: 10.1128/IAI.00910-17. (PDF）
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Okagawa T, Konnai S, Nishimori A, Maekawa N, Goto S, Ikebuchi R, Kohara J, Suzuki Y, Yamada S, Kato Y, Murata S, Ohashi K.
Cooperation of PD-1 and LAG-3 in the exhaustion of CD4+ and CD8+ T cells during bovine leukemia virus infection
Vet Res.,49(1):50. doi: 10.1186/s13567-018-0543-9., 2018 (PDF)
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Retzbach EP, Sheehan SA, Nevel E, Batra A, Phi T, Kato Y, Baredes S, Fatahzadeh M, Shienbaum AJ, and Goldberg GS.
Podoplanin emerges as a functionally relevant oral cancer biomarker and therapeutic target.
Oral Oncology, 78, 126–136, 2018 (PDF)
抗体バンクからの抗ポドプラニン抗体の提供

Tabata S, Kitago Y, Fujii Y, Mihara E, Tamura-Kawakami K, Norioka N, Takahashi K, Kaneko MK, Kato Y, Takagi J.
An anti-peptide monoclonal antibody recognizing the tobacco etch virus protease-cleavage sequence and its application to a tandem tagging system.
Protein Expr Purif., 147, 94-99, doi: 10.1016/j.pep.2018.03.004, 2018 (PDF)
支援課題、領域内連携

Miyazaki A, Nakai H, Sonoda T, Hirohashi Y, Kaneko MK, Kato Y, Sawa Y, Hiratsuka H.
LpMab-23-recognizing cancer-type podoplanin is a novel predictor for a poor prognosis of oral cancer.
Oncotarget,9(30):21156-21165. https://doi.org/10.18632/oncotarget.24986, 2018 (PDF)
抗体バンクからの抗ポドプラニン抗体の提供

Yamamichi A, Ohka F, Aoki K, Suzuki H, Kato A, Hirano M, Motomura K, Tanahashi K, Chalise L, Maeda S, Wakabayashi T, Kato Y, Natsume A.
Immunohistochemical ATRX loss cannot be a surrogate for 1p19q codeletion.
Brain Tumor Pathol., 35(2):106-113, doi: 10.1007/s10014-018-0312-5., 2018 (PDF)
抗体バンクからの抗ポドプラニン抗体の提供

Ito A, Ohta M, Kato Y, Inada S, Kato T, Nakata S, Yatabe Y, Goto M, Kaneda N, Kurita K, Nakanishi H, Yoshida K.
A real time near-infrared imaging method for the detection of oral cancers in mice using an indocyanine green-labeled podoplanin antibody.
Technol Cancer Res Treat., 17:1533033818767936. doi: 10.1177/1533033818767936., 2018 (PDF）
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Masui K, Komori T, Kato Y, Masutomi K, Ichimura K, Ogasawara S, Kaneko MK, Oki H, Suzuki H, Nitta M, Maruyama T, Muragaki Y, Kawamata T, Sawada T, Shibata N.
Elevated TERT Expression in TERT Wild-Type Adult Diffuse Gliomas: Histological Evaluation with a Novel TERT-Specific Antibody
Biomed Res Int.:7945845. doi: 10.1155/2018/7945845., 2018 (PDF)
抗体バンクからの抗ポドプラニン抗体の提供

Suzuki T, Takakubo Y, Oki H, Liu X, Honma R, Naganuma Y, Goodman S, Kaneko MK, Kato Y, Takagi M.
Immunohistochemical Analysis of Inflammatory Rheumatoid Synovial Tissues Using Anti-Human Podoplanin Monoclonal Antibody Panel.
Monoclon. Antib. Immunodiagn. Immunother., 37(1): 12-19, 2018 (PDF)
抗体バンクからの抗ポドプラニン抗体の提供

Nuemket N, Yasui N, Kusakabe Y, Nomura Y, Atsumi N, Akiyama S, Nango E, Kato Y, Kaneko MK, Takagi J, Hosotani M, Yamashita A.
Structural basis for perception of diverse chemical substances by T1r taste receptors.
Open Access
Nature Communications, 23;8:15530, 2017 (PDF)
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Tamahara T, Ochiai K, Muto A, Kato Y, Sax N, Matsumoto M, Koseki T, Igarashi K.
mTOR-Bach2 cascade controls cell cycle and class switch recombination during B cell differentiation.
Mol Cell Biol., doi: 10.1128/MCB.00418-17., 2017
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Maekawa N, Konnai S, Takagi S, Kagawa Y, Okagawa T, Nishimori A, Ikebuchi R, Izumi Y, Deguchi T, Nakajima C, Kato Y, Yamamoto K, Uemura H, Suzuki Y, Murata S, Ohashi K.
A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma.
Sci Rep. ,7(1):8951. doi: 10.1038/s41598-017-09444-2, 2017
支援課題

K Yoshitani, Y Hizukuri, Y Akiyama.
An in vivo protease activity assay for investigating the functions of the Escherichia coli membrane protease HtpX
FEBS Lett. 2019 Mar 22. doi: 10.1002/1873-3468.13368. [Epub ahead of print]
支援課題

Wang H, Han W, Takagi J, Cong Y.
Yeast inner-subunit PA–NZ-1 labeling strategy for accurate subunit identification in a macromolecular complex through cryo-EM analysis.
J Mol Biol. 2018 Apr 3. pii: S0022-2836(18)30177-3. doi: 10.1016/j.jmb.2018.03.026. [Epub ahead of print]
抗体バンクからのNZ-1抗体（抗PAtag抗体）の提供、領域内連携

Brown ZP, Arimori T, Iwasaki K, Takagi J.
Development of a new protein labeling system to map subunits and domains of macromolecular complexes for electron microscopy.
J Struct Biol. 2017 Nov 21. pii: S1047-8477(17)30195-8. doi: 10.1016/j.jsb.2017.11.006. [Epub ahead of print] PMID:29170031
抗体バンクからのNZ-1抗体（抗PAtag抗体）の提供、領域内連携

Masamichi Naga, Yasuhiko Kizuk, Emiko Mihar, Yu Kitago, Shinya Hanashima, Yukishige Ito, Junichi Takagi, Naoyuki Taniguchi & Yoshiki Yamaguchi.
Structure and mechanism of cancer-associated N-acetylglucosaminyltransferase-V
Nature Communicationsvolume 9, Article number: 3380 (2018)
抗体バンクからのNZ-1抗体（抗PAtag抗体）の提供、領域内連携

Arimori T, Kitago Y, Umitsu M, Fujii Y, Asaki R, Tamura-Kawakami K, Takagi J.
Fv-clasp: An Artificially Designed Small Antibody Fragment with Improved Production Compatibility, Stability, and Crystallizability.
Structure. 2017 Oct 3;25(10):1611-1622.e4. doi: 10.1016/j.str.2017.08.011. Epub 2017 Sep 14. PMID: 28919443
抗体バンクからのNZ-1抗体（抗PAtag抗体）の提供、領域内連携