参考文献

1.Kato Y. et al., Inhibition of tumor cell-induced platelet aggregation using a novel anti-podoplanin antibody reacting with its platelet- aggregation-stimulating domain. BBRC, 2006 Nov 3;349(4):1301-1307.(NZ-1抗体を樹立した論文)

2.Kaneko M.K., Kato Y., et al., Functional glycosylation of human podoplanin: glycan structure of platelet aggregation-inducing factor. FEBS letters, 2007.(NZ-1抗体によりポドプラニンの精製を行った論文)

3.Suzuki-Inoue K, Kato Y et al., Involvement of the snake toxin receptor CLEC-2 in podoplanin-mediated platelet activation by cancer cells. J Biol Chem. 2007(ポドプラニンのレセプターを発見した論文;NZ-1抗体を使用)

4.Kato Y. et al., Molecular analysis of pathophysiological binding of the platelet aggregation-inducing factor podoplanin to the C-type lectin-like receptor CLEC-2. Cancer Science, 2008(NZ-1による転移抑制効果を示した論文)

5.Ogasawara S. et al., Characterization of anti-podoplanin monoclonal antibodies: critical epitopes for neutralizing the interaction between podoplanin and CLEC-2. Hybridoma, 27(4), 259-267, 2008(抗ポドプラニン抗体のエピトープ解析)

6.Kato Y. et al., Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas. Nucl. Med. & Biol.,37(7), 785-794, 2010(NZ-1の体内動態解析)

7.Kunita et al., Podoplanin is regulated by AP-1 and promotes platelet aggregation and cell migration in osteosarcoma. Am J Pathol. 2011 Aug;179(2):1041-9.(NZ-1抗体を使用)

8.Honma M, et al., Podoplanin expression in wound and hyperproliferative psoriatic epidermis: Regulation by TGF-β and STAT-3 activating cytokines, IFN-γ, IL-6, and IL-22. J Dermatol Sci. 2011 Dec 8. [Epub ahead of print] (NZ-1抗体を使用)

9. Ishizawa K., et al., Podoplanin is a potential marker for the diagnosis of ependymoma: a comparative study with epithelial membrane antigen (EMA). Clin Neuropathol. 2009 Sep-Oct;28(5):373-8.(NZ-1抗体を使用)

10.Hatakeyama K, et al., Podoplanin expression in advanced atherosclerotic lesions of human aortas. Thromb. Res. 129: 70?76, 2012(NZ-1抗体を使用)

11.Kaji C, et al., Development of novel rat monoclonal antibodies against mouse and human podoplanin. Acta Histochm. Cytochem., 45 (4): 227?237, 2012(NZ-1.2とPMab-1の樹立)

12.Motomura K, et al., Immunohistochemical analysis-based proteomic subclassification of newly diagnosed glioblastomas. Cancer Sci., 103(10):1871-9., 2012(NZ-1.2を使用した論文)

13.Kaneko MK, et al., A chimeric anti-podoplanin antibody suppresses tumor metastasis via neutralization and antibody-dependent cellular cytotoxicity. Cancer Sci. 103 (11), 1913?1919, 2012(NZ-8の樹立)

14.Chandramohan V, Bao X, Kaneko MK, Kato Y, Keir ST, Szafranski S, Kuan CT, Pastan I, Bigner DD. Recombinant anti-podoplanin (NZ-1) immunotoxin for the treatment of malignant brain tumors. Int. J. CancerD, in press(NZ-1の単鎖抗体の開発)